This material is based upon work supported by the National Science Foundation under Grant No. 0923010. Any opinions, findings and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the National Science Foundation (NSF).
The Gates lab is interested in understanding how cells organize themselves into tissues and organs during development. This process often requires extensive changes in cell shape, cell rearrangements and cell migration, all of which are driven by modification of the actin cytoskeleton. Our research focuses on proteins that are responsible for modifying the actin cytoskeleton and how altering the levels, localization or activity of these proteins affects cell behavior during development of the fruit fly, Drosophila melanogaster.
These panels show the localization of actin filaments during the process of dorsal closure in the Drosophila embryo. During dorsal closure the edges of the outer epithelial layer move toward each other (A, arrows) and eventually fuse along the dorsal midline (B, arrows). Images taken by Kate Bowen '12.
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